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Review Article

Volume 7 | Issue 5

Diagnosis of Malignancy and Other Pathologies from Bad Breath: Putative Molecules and Analysis of Oral Malodor, Using Gas Chromatography

Louis ZG Touyz*

McGill University School of Dental Health and Associated Sciences, Montreal, Quebec, Canada

*Corresponding Author: Louis ZG Touyz, McGill University School of Dental Health and Associated Sciences, Montreal, Quebec, Canada.

Received: March 14, 2024; Published: April 12, 2024

     Rapid diagnosis of pathologies, including oncology, is a major challenge in medical practice. Oral malodor is ubiquitously associated with local mouth pathologies but is rarely used for diagnosing remote pathologies or systemic disease. Oral malodors are not all the same. This appraisal re-affirms different types of oral and non-oral malodors as ozaena, ozostomia, halitosis, or stomatodysodia and indicates how using gas-chromatography (GC) on stomatodysodia evaluates common oral malodors and how by using GC to investigate exhaled breath is becoming a promising method for screening and diagnosing remote pathologies and/or associated comorbidities, to provide a rapid, accurate, reliable and affordable diagnosis may facilitate rapid, and accurate diagnosis of disease, by identifying specific GC patterns of volatile organic compounds (VOC) derived from specific pathologies including cancers.

 

Keywords: Breath; Olfaction; Exhaled; Oral-Malodor; Halitosis; Ozaena; Gas-Chromatography; diagnosis; Stomatodysodia; Smell

  1. Touyz LZG. Humps and bumps: feel them… like it or lump it. Current Oncology. 2012;19(3):e115-116.
  2. Touyz LZG. Oral malodor – A review. Jnl Can Dent Assoc. 1993;59(7):607-611.
  3. Touyz LZG. Oral malodor: A clinical appraisal: mechanism¸ diagnosis & therapy. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2013;11(6):85-89.
  4. Zarzo M. The sense of smell: molecular basis of odorant recog-nition. Biol Rev Camb Philos Soc. 2007;82(3):455-479.
  5. Cain WS. Testing olfaction in a clinical setting. Ear Nose Throat J. 1989;68(4):316, 322-318.
  6. Touyz LZG. An oncolfaction molecule? Canine olfaction for oncology screening and diagnosis? EC Neurology. 2023;15(2):03-06.
  7. Bijland LR, Bomers MK, Smulders YM. Smelling the diagnosis: a review on the use of scent in diagnosing disease. Neth J Med. 2013;71(6):300-307.
  8. Rosenberg M, Kulkarni GV, Bosy A, McCulloch CAG. Reproducibility and sensitivity of Oral Malodor measurements with a portable Sulfide Monitor. J Dent Res. 1991a;70(11):1436- 1440.
  9. Chan ECS, Siboo R, Touyz L.Z.G, Qiu A, Klitorinos A. A successful method for quantifying viable oral anaerobic spirochetes. Oral Microbiology and Immunology. 1993;8(2):80-83.
  10. Cometo-Muniz JE, Cain WS, Abraham MH. Quantification of chemical vapors in chemosensory research. Chem Senses. 2003;28(6):467-477.
  11. Skeldon KD, McMillan LC, Wyse CA, Monk SD, Gibson G, Patterson C. Application of laser spectroscopy for measurement of exhaled ethane in patients with lung cancer. Respiratory medicine. 2006;100(2):300-306.
  12. Larsson M, Finkel D, Pedersen NL. Odor identification: influences of age, gender, cognition, and personality. J Gerontol B Psychol Sci Soc Sci. 2000;55(5):P304-P310.
  13. Hawkes CH, Doty RL. The Neurobiology of Olfaction. Cambridge University Press, Cambridge, United Kingdom, 2009.
  14. Wright RH. Odor and molecular vibration: neural coding of olfactory information. J Theor Biol. 1977;64(3):473-502.
  15. Turin L. (2002). www.physiol.ucl.ac.uk/research/turin_1/chemical_senses_complete.pdf
  16. Bollen CM, Beikler T. Halitosis: the multidisciplinary approach. International Journal of Oral Science. 2012;4(2):55-63.
  17. Pause BM. Processing of body odor signals by the human brain. Chemosens Percept. 2012;5(1):55-63.
  18. Rosenberg M. The science of bad breath. Scientific American. 2002;286(4):72-79.
  19. Zamani M, et al. Systematic review with meta-analysis: the worldwide prevalence of Helicobacter pylori infection. Ailment Pharmacol Ther. 2018;47(7):868-876.
  20. Warren JR, Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1(8336):1273-1275.
  21. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process–First American Cancer Society Award Lecture on Cancer, 1992.
  22. Louten J. Detection and diagnosis of viral infections. Essential Human Virology. 2016:111-132.
  23. Xiong Meng MM, Yu Chang MM, Ren Baoping MM, Zhong Meiqi MM, et al. Global knowledge mapping and emerging trends in Helicobacter pylori-related precancerous lesions of gastric cancer research: A bibliometric analysis from 2013 to 2023. Medicine. 2023;102(48):e36445.
  24. Traxler S, et al. VOC breath profile in spontaneously breathing awake swine during Influenza A infection. Sci Rep. 2018;8:14857.
  25. Gralton J, et al. Respiratory virus RNA is detectable in airborne and droplet particles. J Med Virol. 2013;85(12):2151-2159.
  26. F.D.A. Coronavirus (COVID-19) 2022-update: FDA authorizes first COVID-19 diagnostic test using breath samples (2022).
  27. Horvath G, Jarverud GA, Jarverud S, Horvath I. Human ovarian carcinomas detected by specific odor. Integr Cancer Ther. 2008;7(2):76-80.
  28. Gruber M, Tisch U, Jeries R, Amal H, Hakim M, et al. Analysis of exhaled breath for diagnosing head and neck squamous cell carcinoma: a feasibility study. British Journal of Cancer. 2014;111(4):790-798.
  29. Chirambo AC, et al. Performance of molecular methods for the detection of Salmonella in human stool specimens. Wellcome Open Res. 2021;5:237.
  30. Wilson ML. Development of new methods for detecting bloodstream pathogens. Clin Microbiol Infect. 2020;26(3):319-324.
  31. Saktiawati AMI, et al. Diagnosis of tuberculosis through breath test: A systematic review. EBioMedicine. 2019;46:202-214.
  32. Koo S, et al. A breath fungal secondary metabolite signature to diagnose invasive aspergillosis. Clin Infect Dis. 2014;59(12):1733-1740.
  33. Kennedy CC, Razonable RR. Fungal infections after lung transplantation. Clin Chest Med. 2017;38(3):511-520.
  34. Haripriya P. Breath VOC analysis and machine learning approaches for disease screening: a review. J Breath Res. 2023;17(2).
  35. Le Maout P, et al. Polyaniline nano-composites based sensor array for breath ammonia analysis. Portable e-nose approach to non-invasive diagnosis of chronic kidney disease. Sens Actuators B: Chem. 2018;274:616-626.
  36. Frinculescu A, Shine T, Ramsey J, Couchman L, Nunzianda F, Abbate V. Analysis of drugs seized from amnesty bins at two major United Kingdom summer music festivals using two portable gas chromatography-mass spectrometry (GC-MS) instruments. Drug Test Anal. 2024.
  37. Zinger A, Broza YY, Shroeder A, Haick H. Artificially intelligent nanoarray detects various cancers by liquid biopsy of volatile markers. advanced health care materials. 2022;11(17):e2200356.
  38. Griffin G510 (Flir Systems) and Torion T-9 (2024) (PerkinElmer).

Louis ZG Touyz. “Diagnosis of Malignancy and Other Pathologies from Bad Breath: Putative Molecules and Analysis of Oral Malodor, Using Gas Chromatography”. Scientific Archives Of Dental Sciences 7.5 (2024): 02-05.

© 2024 Louis ZG Touyz. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.